High-Grade Squamous Lesions - NCPTS

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Welcome to your quiz on high grade squamous lesions

What is the expected nuclear-to-cytoplasmic (N:C) ratio typically observed in HSIL predictive of CIN3?

Greater than 65%

Less than 50%

Between 50-65%

Approximately 50%

None

In diagnosing HSIL, what is considered more reliable than any other single abnormal criterion?

A specific chromatin pattern observed within the nucleus

The presence of macronucleoli

Unpredictable variation within the abnormal cell population

The N:C ratio

None

What nuclear feature should raise concern in parakeratotic cells?

A nucleus smaller and lighter than other nuclei in the group

Larger and darker nuclei than other nuclei in the group

Uniformly small, condensed nuclei

Very small or absent nuclei

None

What characteristic is associated with parakeratotic CIN3 cells?

Abundant cytoplasm compared to typical HSIL cells

High N:C ratio

Nucleoli are prominent

Small cells with relatively more cytoplasm than is usual with HSIL

None

Invasive Squamous Cell Carcinoma (SCC) diagnosis by cytology can be challenging due to what factor?

Lack of cellular material

Presence of bleeding, inflammation, ulceration, or necrosis

Uniformity of malignant cells

Well-defined features of invasion seen on histology are absent

None

What is a typical characteristic of the nuclear chromatin pattern seen in SCC but not in HSIL?

Finely granular chromatin

Hyperchromasia

Irregular nuclear membranes

Clumping and clearing

None

What is tumour diathesis composed of?

Blood and normal squamous cells

Blood, leucocytes, and degenerate cellular material

Bacteria and inflammatory cells

Keratin debris

None

Which cellular shape is characteristic of keratinizing SCC?

Columnar

Cuboidal

Spindle or tadpole

Uniformly round

None

In non-keratinizing SCC, the cells can sometimes closely resemble which other type of lesion?

Benign squamous cells

HSIL

AIS

Metaplastic cells

None

What is the typical range of the nucleus occupying the cell in CIN2?

>65%

<50%

50-65%

>90%

None

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